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Induced expression of ectopic myelin genes by the transcription factor SOX10 in an enteric glial cell line

ABSTRACT: This study investigates the impact of Sox10 overexpression on enteric glial cell (EGC) phenotype using a doxycycline-inducible EGC cell line. Sox10 overexpression upregulated genes were associated with myelin regulation and glial differentiation pathways, resembling Schwann cell or oligodendrocyte-specific SOX10 target genes. These findings suggest cell-specific regulation of glial phenotype by SOX10 dosage and identify potential target genes, contributing to our understanding of EGC diversity.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE249205 | GEO | 2025/02/26

REPOSITORIES: GEO

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