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Single-nucleus transcriptomic highlights sex differences in cardiac molecular signaling and identifies a novel cardiomyocyte population associated with CCNA2-mediated cardiac regeneration

ABSTRACT: Adult mammalian hearts lack regenerative potential and this is a significant contributing cause of the extensive morbidity and mortality of cardiovascular disease. We performed single nucleus RNA sequencing (snRNA-seq) to capture of cell diversity and gender-specific changes as well as identification of critical differentially expressed genes in cellular clusters throughout the heart.

ORGANISM(S): Mus musculus

PROVIDER: GSE249433 | GEO | 2023/12/06

REPOSITORIES: GEO

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