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DNA methylation profiles of SMARCB1-deficient T cell lymphomas

ABSTRACT: Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of malignancies with poor outcome. Here we have identified a subgroup of SMARCB1 deficient PTCL-NOS, which is characterized by the lack of the SMARCB1 protein and is more common in young patients. Human and murine Smarcb1-negative PTCL-NOS from a corresponding mouse model show similar DNA methylation profiles, with hypermethylation of T-cell-related genes and hypomethylation of genes involved in myeloid development.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE249566 | GEO | 2024/07/16

REPOSITORIES: GEO

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