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Characterizing preeclamptic developmental lung injury pathways through human placental spatial transcriptomics

ABSTRACT: Bronchopulmonary dysplasia (BPD) continues to impact the health of preterm infants worldwide. Preeclampsia (PE), a placental-driven pregnancy disorder, has a strong clinical association with BPD risk. We hypothesize that preeclampsia causes a unique type of developmental lung injury that predisposes infants to an increased risk of BPD. Research on human placental tissues is needed to more clearly define the role of PE in developmental lung injury. A new approach to human placental analysis is spatial transcriptomics (Sp-Tr), a technique which produces spatially oriented gene expression data from cells in their native tissue environment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE249899 | GEO | 2024/12/31

REPOSITORIES: GEO

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