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Liver in humanized-liver mice: Control vs acetoaceto-o-toluidide treatment

ABSTRACT: The gene expression profiling between Control and acetoaceto-o-toluidide exposure for 4 weeks in liver of NOG-TKm30 female mice transplanted with commercially available human hepatocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE250079 | GEO | 2025/01/29

REPOSITORIES: GEO

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Liver in humanized-liver mice: Control vs ortho-toluidine treatment

Project description:The gene expression profiling between Control and ortho-toluidine exposure for 4 weeks in liver of NOG-TKm30 female mice transplanted with commercially available human hepatocytes.

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Liver in humanized-liver mice: Control vs 4,4'-Methylenebis(2-chlorobenzenamine) treatment

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Liver in NOG-TKm30 mice: Control vs ortho-toluidine treatment

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Liver in NOG-TKm30 mice: Control vs acetoaceto-o-toluidide treatment

Project description:The gene expression profling between Control and acetoaceto-o-toluidide exposure for 4 weeks in liver of NOG-TKm30 female mice.

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Liver in NOG-TKm30 mice: Control vs ortho-toluidine treatment

Project description:Liver in NOG-TKm30 mice: Control vs ortho-toluidine treatment

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Liver in NOG-TKm30 mice: Control vs acetoaceto-o-toluidide treatment

Project description:Liver in NOG-TKm30 mice: Control vs acetoaceto-o-toluidide treatment

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Liver in F1-TKm30 mice: Control vs 4,4'-Methylenebis(2-chlorobenzenamine) treatment

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Project description:Humanized NOG-EXL (huNOG-EXL) mice control P. murina infection significantly better than control NOG-EXL mice, as evidenced by markedly decrased lung fungal burdens at both 3 and 6 weeks post-infection. Human cytokine-generating CD4+ and CD8+ T cells in the lung and serum IgM antibody, which were specifically in responses to pneumocystis antigen, were detected in huNOG-EXL mice only. For humanized NOG-EXL mouse group at 6 weeks post-infection, the whole lung RNAseq analyses were performed and the data indicated that the lower lung fungal burden is associated with higher CD209 gene expression.

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