Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome changes of OA rat synovium before and after the injection of human SyMSCs and AdMSCs

ABSTRACT: To clarify the effect of factors produced by human SyMSCs and AdMSCs on OA synovium, we performed RNA sequencing for OA rat synovium before and after the injection of human SyMSCs and AdMSCs.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE250102 | GEO | 2024/09/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptome changes of SyMSCs and AdMSCs before and after the injection into rat OA knees

Project description:To clarify similarities/differences in factors produced by SyMSCs and AdMSCs under OA environment, we performed RNA sequencing for SyMSCs and AdMSCs before and after the injection into rat OA knees.

2024-07-11 | GSE250042 | GEO

Transcriptome changes of OA rat synovium before and after the injection of human SyMSCs and AdMSCs

Project description:Transcriptome changes of OA rat synovium before and after the injection of human SyMSCs and AdMSCs

| PRJNA1052032 | ENA

Human transcripts up-regulated in the human mesenchymal stem cells migrated within the rat synovium; rat transcripts up-regulated in the rat synovium after human mesenchymal stem cells injection

2014-10-27 | GSE61617 | GEO

Dysregulated gene expression in human osteoarthritic (OA) and rheumatoid arthritis (RA) synovium

Project description:Osteoarthritis (OA) causes pain and functional disability for over 500 million people worldwide and is characterized by progressive loss of cartilage and synovial hyperplasia from the articulating surfaces of diarthrodial joints. Although the etiology of the disease is unknown, it is widely accepted that these degenerative changes arise from an imbalance of synthetic and degradative pathways that control cartilage and synovium extracellular matrix metabolism. Genome-wide U133A Affymetrix oligonucleotide array set was used to comprehensively investigate the expression pattern in non-osteoarthritis (normal) and synovium obtained from OA and rheumatoid arthritis (RA) patients undergoing knee replacement surgery. This study was undertaken to understand the disease's molecular basis better and provide relevant insight into phenotypical alterations and mechanisms involved in OA pathogenesis.

2022-08-01 | GSE206848 | GEO

Transcriptome changes of SyMSCs and AdMSCs before and after the injection into rat OA knees

Project description:Transcriptome changes of SyMSCs and AdMSCs before and after the injection into rat OA knees

| PRJNA1051649 | ENA

Human transcripts up-regulated in the human mesenchymal stem cells migrated within the synovium

Project description:After the injection of human synovial mesenchymal stem cells into the rat (Lewis strain) knee joint, synovium was investigated using species specific microarray analyses of human and rat transcripts to investigate the gene expression change after injection. Human synovial mesenchymal stem cells were injected into the rat anterior cruciate ligament transected knee. After harvesting the synovium and extraction of RNA, species specific microarray analyses were performed uisng Affymetrix microarrays to investigate the gene expression change of human and rat transcripts after injection.

2014-09-22 | E-GEOD-61617 | biostudies-arrayexpress

Human transcripts up-regulated in the human mesenchymal stem cells migrated within the rat synovium rat transcripts up-regulated in the rat synovium after human mesenchymal stem cells injection

Project description:Human transcripts up-regulated in the human mesenchymal stem cells migrated within the rat synovium rat transcripts up-regulated in the rat synovium after human mesenchymal stem cells injection

| PRJNA261694 | ENA

Dysregulated gene expression in human osteoarthritic (OA) and rheumatoid arthritis (RA) synovium

Project description:Dysregulated gene expression in human osteoarthritic (OA) and rheumatoid arthritis (RA) synovium

| PRJNA852422 | ENA

Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis

Project description:Osteoarthritis (OA) affects nearly 10% of the population of the United States and other industrialized countries and, at present, short of surgical joint replacement, there is no therapy available that can reverse the progression of the disease OA. Adenosine, acting at its A2A receptor (A2AR), is a critical autocrine factor for maintenance of cartilage homeostasis. Here we report that injection of liposomal suspensions of a selective A2AR agonist, CGS21680, significantly reduced OA cartilage damage in a rat model of established post-traumatic OA (PTOA). Differential expression analysis of mRNA from chondrocytes harvested from knees of rats with PTOA treated with liposomal A2AR agonist revealed downregulation of genes associated with matrix degradation and upregulation of genes associated with cell proliferation as compared to liposomes alone.

2020-09-01 | GSE146813 | GEO

Pain-driven transcriptome changes in synovium of knee osteoarthritis patients

Project description:Objectives : Joint pain causes a significant morbidity in osteoarthritis (OA). The synovium as an innervated joint structure might contribute to the peripheral pain in OA. Methods : We used a hypothesis-free next generation RNA sequencing to study protein coding and small non-coding transcriptomes in knee synovial tissues of OA patients (n=10) with high and low knee pain (evaluated by visual analogue scale) followed by Gene Ontology (GO) and pathway analyses and integration of mRNAs and small RNAs data sets. Results : We showed that 33 protein-coding genes and 35 small RNAs were differentially expressed in the knee synovium of patients with high compared to low intensity knee pain, with 30 mRNAs and 14 small RNAs being upregulated and 2 mRNAs and 21 small RNAs being downregulated. Top enriched genes, such as SDIM1 and CPE encode neuronal proteins that share molecular properties with neurotrophic factor BDNF and promote neuronal survival under cellular stress, and OTOF participates in calcium-dependent synaptic exocytosis and modulation of GABAergic activity. TrkB was enriched in several gene networks, suggesting its key role in pain-related transcriptional changes in OA joint. Downregulation of PTX3 in high pain group supports an argument that inflammation and pain are independent processes in symptomatic knee OA. MiR-146a-3p and miR150 appeared as the microRNA candidates in the pathogenesis of OA-related knee pain. Conclusions : Here we uncovered the molecular complexity of pain-related transcriptome changes in the synovium of knee joints in osteoarthritis. We identified new molecular candidates in OA pain setting a firm ground for future mechanistic studies and drug discovery in OA.

2018-11-05 | GSE99662 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data