Effect of RANKL inhibition on fibrous dysplasia lesions (mouse)
Ontology highlight
ABSTRACT: we investigated mechanisms underlying RANKL inhibition with the monoclonal antibody denosumab on FD tissue, and its likely indirect effects on osteoprogenitors, by evaluating human FD tissue pre and post-treatment and in murine in vivo pre-clinical models. Results from this study demonstrate that, beyond its expected anti-osteoclastic effects, denosumab reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic maturation, leading to increased bone formation within lesions
ORGANISM(S): Mus musculus
PROVIDER: GSE250356 | GEO | 2024/01/15
REPOSITORIES: GEO
ACCESS DATA