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Identifying super-enhancer-derived signatures with prognostic value through selective inhibitors (Microarray gene expression data)

ABSTRACT: CDK12 and CDK13 promote transcription elongation within the gene body and regulate the processivity of RNAPII. THZ531 inhibits the enzymatic activity of CDK12 and 13 through covalent binding. Gene expression profiling was performed to investigate the THZ531-induced transcription effect, and search the subset of sensitive genes in osteosarcoma cell lines, U2-OS and SJSA-1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE250566 | GEO | 2024/01/31

REPOSITORIES: GEO

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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors [Affymetrix]

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