Comparison of genes differentially expressed among effectors with high and low memory potential
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ABSTRACT: The events controlling transition of T cells from effector to memory remain poorly understood. Herein, we defined two types of effectors on the basis of cell division, expression of activation markers and production of effector cytokines and investigated their potential for memory generation. The results indicated that the moderately activated early effectors readily transit to memory while highly activated late effectors develop minimal memory. Boosting with antigen-free adjuvant, however, rescues the late effectors from cell death and sustains both survival and cytokine responses through toll-like receptor function. Also, the genome-wide microarray analysis among early and late effectors pointed to a set og defined as well as less known genes that may play a role in transition to memory.
ORGANISM(S): Mus musculus
PROVIDER: GSE25141 | GEO | 2011/01/01
SECONDARY ACCESSION(S): PRJNA134479
REPOSITORIES: GEO
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