Transcriptomics

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CREB3L1 Target Genes in Response to Hepatitis C Replicon Infection


ABSTRACT: Membrane-bound transcription factor CREB3L1 undergoes Regulated Intramembrane Proteolysis (RIP) in response to Hepatitis C infection. RIP activates CREB3L1 so that it can prevent the growth of HCV infected cells through the action of downstream genes. We over-expressed a truncated form of CREB3L1 that does not require RIP to enter the nucleus. Cells over-expressing this truncated form were isolated by Fluorescence Activated Cell Sorting (FACS). We used microarray to determine the downstream genes of CREB3L1 in comparison to a flow sorted empty vector control.

ORGANISM(S): Homo sapiens

PROVIDER: GSE25157 | GEO | 2011/05/01

SECONDARY ACCESSION(S): PRJNA134345

REPOSITORIES: GEO

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