Transcriptomics

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NF1 deficiency drives metabolic reprogramming in ER+ breast cancer


ABSTRACT: NF1 deficiency drives metabolic reprogramming in ER+ breast cancer. This reprogramming is characterized by oxidative ATP constraints, glutamine TCA influx, and lipid pool expansion, and these metabolic changes introduce novel metabolic-to-targeted inhibitor synergies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE251692 | GEO | 2023/12/25

REPOSITORIES: GEO

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