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CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE252231 | GEO | 2024/01/05

REPOSITORIES: GEO

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CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression [RNA-seq]

Project description:Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality worldwide. Understanding the dysregulated epigenetics governing LUAD progression is pivotal for identifying therapeutic targets. CBX4, a chromobox protein, is reported to be upregulated in LUAD. However, its regulatory role in LUAD progression warrants in-depth investigation. This study highlights the dual impact of CBX4 on LUAD proliferation and metastasis. Through a series of rigorous in vitro and in vivo experiments, we elucidate that CBX4 functions in promoting LUAD proliferation via upregulating PHGDH expression while concurrently suppressing LUAD metastasis by inhibiting ZEB2 transcription. Further investigation into the underlying mechanism reveals CBX4’s intricate interactions with distinct epigenetic factors. The inhibition of ZEB2 transcription involves CBX4-mediated recruitment of canonical PRC1 (cPRC1), establishing H2K119ub on the ZEB2 promoter. Simultaneously, CBX4 facilitates PHGDH transcription through interaction with GCN5, inducing heightened histone acetylation on the PHGDH promoter. These findings underscore CBX4's pivotal role as a regulator of LUAD progression, emphasizing its diverse transcriptional regulatory functions contingent upon interactions with specific epigenetic partners. Understanding the nuanced interplay between CBX4 and epigenetic factors sheds light on potential therapeutic avenues in LUAD.

2024-01-05 | GSE252181 | GEO

CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression [ChIP-Seq]

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CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression

Project description:CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression

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CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression [ChIP-Seq]

Project description:CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression [ChIP-Seq]

| PRJNA1058959 | ENA

CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression [RNA-seq]

Project description:CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression [RNA-seq]

| PRJNA1058436 | ENA

HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1.

Project description:Lung adenocarcinoma (LUAD) is a fatal threat to human health, while the mechanism remains unclear, and the therapy brings limited therapeutic effects. Transcription factor Homeobox C11 (HOXC11) was previously proved to be related to hind limbs and metanephric development during the embryonic phase, and its role in tumors has been gradually recognized. Our study found that HOXC11 overexpressed in LUAD and was associated with worse overall survival. Moreover, its expression in lung cancer was regulated by IκB kinase α (IKKα), a pivotal kinase in NF-κB signaling, which was related to the ubiquitination of HOXC11. We further proved that HOXC11 could enhance the ability of proliferation, migration, invasion, colony formation, and the progression of the cell cycle in LUAD cells. Meanwhile, it also accelerated the formation of subcutaneous and lung metastases tumors. In contrast, loss of HOXC11 in LUAD cells significantly inhibited these malignant phenotypes. At the same time, HOXC11 regulated the expression of sphingosine kinase 1 (SPHK1) by directly binding to its promoter region. Therefore, we conclude that HOXC11 impacts the development of LUAD and facilitates lung cancer progression by promoting the expression of SPHK1.

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Contextual epigenetic regulation of lung adenocarcinoma by GATA6

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-03-05 | GSE124604 | GEO

Lung adenocarcinoma invasion and progression

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2011-09-14 | E-GEOD-27719 | biostudies-arrayexpress

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