Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells

ABSTRACT: Understanding prostate response to castration and androgen receptor signaling inhibitors (ARSI) is critical to improving long-term prostate cancer (PCa) patient survival. We use a multi-omics approach on 229,794 single cells to create a mouse single-cell reference atlas better suited to interpreting mouse prostate biology and castration response. Our reference atlas refines single-cell annotations and provides chromatin context, which, when coupled with mouse lineage tracing demonstrates that the castration-resistant luminal cells are distinct from the pre-existent urethra- proximal stem/progenitor cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE252511 | GEO | 2024/06/14

REPOSITORIES: GEO