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Tissue-resident memory T cells drive CD103-dependent salivary gland inflammatory infiltration in primary Sjogren's syndrome

ABSTRACT: Tissue resident memory cells (Trm) are a specialized subset of T cells residing persistently and long-term within specific tissues that contribute to persistent inflammation, tissue damage, and aberrant immune responses. Expansion of Trm in the salivary gland of primary Sjogren’s Syndrome (pSS) and its animal models suggests CD103 determines the tissue localization of Trm. We characterized phenotype and function of Trm and the role of CD103 in pSS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE252724 | GEO | 2024/10/15

REPOSITORIES: GEO

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Tissue-resident memory T cells drive CD103-dependent salivary gland inflammatory infiltration in primary Sjogren's syndrome

Project description:Tissue-resident memory T cells drive CD103-dependent salivary gland inflammatory infiltration in primary Sjogren's syndrome

| PRJNA1062333 | ENA

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