Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE252855 | GEO | 2024/10/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (CUT&Tag)

Project description:To identified ZFP488 binding sites in Ols, we performed Zfp488-HA CUT&Tag-seq to identify site of ZFP488 binding within the genome.

2024-10-02 | GSE252854 | GEO

Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (RNA-Seq)

Project description:To investigate how ZFP488 regulates myelination, we performed transcriptome profiling on OLs (O4+GalC+) isolated from the cortices of control and Zfp488KI/KI mice at P5 using fluorescence activated cell sorting.

2024-10-02 | GSE252853 | GEO

Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination

Project description:Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination

| PRJNA1062818 | ENA

A zinc finger protein that regulates oligodendrocyte specification, migration and myelination in zebrafish.

Project description:Precise control of oligodendrocyte migration and development is crucial for myelination of axons in the central nervous system (CNS), but important questions remain unanswered about the mechanisms controlling these processes. In a zebrafish screen for myelination mutants, we identified a mutation in zinc finger protein 16-like (znf16l). znf16l mutant larvae have reduced myelin basic protein (mbp) expression and reduced CNS myelin. Marker, time-lapse and ultrastructural studies indicated that oligodendrocyte specification, migration and myelination are disrupted in znf16l mutants. Transgenic studies indicated that znf16l acts autonomously in oligodendrocytes. Expression of Zfp488 from mouse rescued mbp expression in znf16l mutants, indicating that these homologs have overlapping functions. Our results defined the function of a new zinc finger protein with specific function in oligodendrocyte specification, migration and myelination in the developing CNS.

| S-EPMC4712842 | biostudies-literature

Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (CUT&Tag)

Project description:Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (CUT&Tag)

| PRJNA1062821 | ENA

Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (RNA-Seq)

Project description:Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (RNA-Seq)

| PRJNA1062822 | ENA

Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination.

Project description:Remyelination requires the generation of new oligodendrocytes (OLs), which are derived from oligodendrocyte progenitor cells (OPCs). Maturation of OPCs into OLs is a multi-step process. Here, we describe a microRNA expressed by OLs, miR-27a, as a regulator of OL development and survival. Increased levels of miR-27a were found in OPCs associated with multiple sclerosis (MS) lesions and in animal models of demyelination. Increased levels of miR-27a led to inhibition of OPC proliferation by cell-cycle arrest, as well as impaired differentiation of human OPCs (hOPCs) and myelination by dysregulating the Wnt-β-catenin signaling pathway. In vivo administration of miR-27a led to suppression of myelinogenic signals, leading to loss of endogenous myelination and remyelination. Our findings provide evidence supporting a critical role for a steady-state level of OL-specific miR-27a in supporting multiple steps in the complex process of OPC maturation and remyelination.

| S-EPMC6874400 | biostudies-literature

Neural zinc finger protein Myt1 drives oligodendrocyte differentiation via repressing HDAC1-mediated histone deacetylation

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-01 | GSE253257 | GEO

Chromatin Remodeler CHD7 mutated in CHARGE Syndrome Interacts with Sox10 to Regulate Timing of CNS Myelination and Remyelination.

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-29 | E-GEOD-72727 | biostudies-arrayexpress

Transcription Factor Promyelocytic Leukemia Zinc Finger Protein regulates Interferon Stimulated Gene expression

Project description:This SuperSeries is composed of the SubSeries listed below.

2009-05-22 | GSE16197 | GEO