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Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE252855 | GEO | 2024/10/02

REPOSITORIES: GEO

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Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (CUT&Tag)

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Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (RNA-Seq)

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Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination

Project description:Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination

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Project description:Precise control of oligodendrocyte migration and development is crucial for myelination of axons in the central nervous system (CNS), but important questions remain unanswered about the mechanisms controlling these processes. In a zebrafish screen for myelination mutants, we identified a mutation in zinc finger protein 16-like (znf16l). znf16l mutant larvae have reduced myelin basic protein (mbp) expression and reduced CNS myelin. Marker, time-lapse and ultrastructural studies indicated that oligodendrocyte specification, migration and myelination are disrupted in znf16l mutants. Transgenic studies indicated that znf16l acts autonomously in oligodendrocytes. Expression of Zfp488 from mouse rescued mbp expression in znf16l mutants, indicating that these homologs have overlapping functions. Our results defined the function of a new zinc finger protein with specific function in oligodendrocyte specification, migration and myelination in the developing CNS.

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Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below.

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