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ChAHP and ChAHP2 control diverse retrotransposons by complementary activities

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE253069 | GEO | 2024/06/25

REPOSITORIES: GEO

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Similar Datasets

ChAHP2 and ChAHP control diverse retrotransposons by complementary activities.

Project description:Retrotransposon control in mammals is an intricate process that is effectuated by a broad network of chromatin regulatory pathways. We previously discovered ChAHP, a protein complex with repressive activity against short interspersed element (SINE) retrotransposons that is composed of the transcription factor ADNP, chromatin remodeler CHD4, and HP1 proteins. Here we identify ChAHP2, a protein complex homologous to ChAHP, in which ADNP is replaced by ADNP2. ChAHP2 is predominantly targeted to endogenous retroviruses (ERVs) and long interspersed elements (LINEs) via HP1β-mediated binding of H3K9 trimethylated histones. We further demonstrate that ChAHP also binds these elements in a manner mechanistically equivalent to that of ChAHP2 and distinct from DNA sequence-specific recruitment at SINEs. Genetic ablation of ADNP2 alleviates ERV and LINE1 repression, which is synthetically exacerbated by additional depletion of ADNP. Together, our results reveal that the ChAHP and ChAHP2 complexes function to control both nonautonomous and autonomous retrotransposons by complementary activities, further adding to the complexity of mammalian transposon control.

| S-EPMC11293393 | biostudies-literature

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ChIP-seq]

Project description:Retrotransposon control in mammals is an intricate process that is effectuated by a broad network of chromatin regulatory pathways. We previously discovered ChAHP, a protein complex with repressive activity against SINE retrotransposons, composed of the transcription factor ADNP, chromatin remodeler CHD4, and HP1 proteins. Here we identify ChAHP2, a protein complex homologous to ChAHP, wherein ADNP is replaced by ADNP2. ChAHP2 is predominantly targeted to ERVs and LINEs, via HP1b-mediated binding of H3K9 trimethylated histones. We further demonstrate that ChAHP also binds these elements in a mechanistically equivalent manner to ChAHP2, and distinct from DNA sequence-specific recruitment at SINEs. Genetic ablation of ADNP2 alleviates ERV and LINE1 repression, which is synthetically exacerbated by additional depletion of ADNP. Together, our results reveal that the ChAHP and ChAHP2 complexes function to control both non-autonomous and autonomous retrotransposons by complementary activities, further adding to the complexity of mammalian transposon control.

2024-06-25 | GSE253066 | GEO

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ATAC-seq]

Project description:Retrotransposon control in mammals is an intricate process that is effectuated by a broad network of chromatin regulatory pathways. We previously discovered ChAHP, a protein complex with repressive activity against SINE retrotransposons, composed of the transcription factor ADNP, chromatin remodeler CHD4, and HP1 proteins. Here we identify ChAHP2, a protein complex homologous to ChAHP, wherein ADNP is replaced by ADNP2. ChAHP2 is predominantly targeted to ERVs and LINEs, via HP1b-mediated binding of H3K9 trimethylated histones. We further demonstrate that ChAHP also binds these elements in a mechanistically equivalent manner to ChAHP2, and distinct from DNA sequence-specific recruitment at SINEs. Genetic ablation of ADNP2 alleviates ERV and LINE1 repression, which is synthetically exacerbated by additional depletion of ADNP. Together, our results reveal that the ChAHP and ChAHP2 complexes function to control both non-autonomous and autonomous retrotransposons by complementary activities, further adding to the complexity of mammalian transposon control.

2024-06-25 | GSE253065 | GEO

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [RNA-seq]

Project description:Retrotransposon control in mammals is an intricate process that is effectuated by a broad network of chromatin regulatory pathways. We previously discovered ChAHP, a protein complex with repressive activity against SINE retrotransposons, composed of the transcription factor ADNP, chromatin remodeler CHD4, and HP1 proteins. Here we identify ChAHP2, a protein complex homologous to ChAHP, wherein ADNP is replaced by ADNP2. ChAHP2 is predominantly targeted to ERVs and LINEs, via HP1b-mediated binding of H3K9 trimethylated histones. We further demonstrate that ChAHP also binds these elements in a mechanistically equivalent manner to ChAHP2, and distinct from DNA sequence-specific recruitment at SINEs. Genetic ablation of ADNP2 alleviates ERV and LINE1 repression, which is synthetically exacerbated by additional depletion of ADNP. Together, our results reveal that the ChAHP and ChAHP2 complexes function to control both non-autonomous and autonomous retrotransposons by complementary activities, further adding to the complexity of mammalian transposon control.

2024-06-25 | GSE253067 | GEO

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities

Project description:ChAHP and ChAHP2 control diverse retrotransposons by complementary activities

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ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [RNA-seq]

Project description:ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [RNA-seq]

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ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ATAC-seq]

Project description:ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ATAC-seq]

| PRJNA1063742 | ENA

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ChIP-seq]

Project description:ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ChIP-seq]

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RNAi triggered by specialized machinery silences developmental genes and retrotransposons

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2012-11-26 | E-GEOD-41643 | biostudies-arrayexpress

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death.

Project description:This SuperSeries is composed of the SubSeries listed below.

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