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Analysis of the developmental function of the PAIRED-Like homeobox transcription factor Drgx in T4/T5 neurons of Drosophila melanogaster [RNA-seq]

ABSTRACT: Targeted DamID was performed to identify binding targets of Drgx in T4/T5 neurons. RNA-seq analysis of differentially expressed genes following the knockdown of Drgx in T4/T5 neurons of late third instar larvae, compared with control.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE253078 | GEO | 2025/01/10

REPOSITORIES: GEO

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Analysis of the developmental function of the PAIRED-Like homeobox transcription factor Drgx in T4/T5 neurons of Drosophila melanogaster [DamID-Seq]

Project description:Targeted DamID was performed to identify binding targets of Drgx in T4/T5 neurons. RNA-seq analysis of differentially expressed genes following the knockdown of Drgx in T4/T5 neurons of late third instar larvae, compared with control.

2025-01-10 | GSE253077 | GEO

mRNA-seq of nuclear RNA extracted from T4 and T5 neurons of D. melanogaster

Project description:T4 and T5 neurons are components of the neuronal circuit for motion vision in flies. To identify genes involved in neuronal computation of T4 and T5 neurons, we perfomed transcriptome analysis. Nuclei of T4 and T5 neurons were immunoprecipitated, total RNA was harvested and used for mRNA-seq with Illumina technology. In two biological replicates, we mapped 154 and 119 million reads to D. melanogaster genome. mRNA-seq provided information about expression levels of 17,468 annotated transcripts in the T4 and T5 neurons.

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mRNA-seq of nuclear RNA extracted from T4 and T5 neurons of D. melanogaster

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Translatome of developing drosophila t4/t5 neurons in wildtype versus atonal loss of function genotypes

Project description:Atonal is a proneural transcription factor expressed in the Drosophila neuroblast cluster known as the inner proliferation center (IPC). The t4/t5 neurons that derived from the IPC require atonal for their normal development. To characterize the role of Atonal in t4/t5 development we have sequenced the translated RNA in t4/t5 neurons in wild type and ato loss of function flies.

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Analysis of the developmental function of the PAIRED-Like homeobox transcription factor Drgx in T4/T5 neurons of Drosophila melanogaster [DamID-Seq]

Project description:Analysis of the developmental function of the PAIRED-Like homeobox transcription factor Drgx in T4/T5 neurons of Drosophila melanogaster [DamID-Seq]

| PRJNA1063785 | ENA

A combinatorial code of transcription factors specifies subtypes of visual motion-sensing neurons in Drosophila

Project description:Direction-selective T4/T5 neurons exist in four subtypes, each tuned to visual motion along one of the four cardinal directions. Along with their directional tuning, neurons of each T4/T5 subtype orient their dendrites and project their axons in a subtype-specific manner. Directional tuning, thus, appears strictly linked to morphology in T4/T5 neurons. How the four T4/T5 subtypes acquire their distinct morphologies development remains largely unknown. Here, we investigated when and how the dendrites of the four T4/T5 subtypes acquire their specific orientations, and profiled the transcriptomes of all T4/T5 neurons during this process. This revealed a simple and stable combinatorial code of transcription factors defining the four T4/T5 subtypes during their development. Changing the combination of transcription factors of specific T4/T5 subtypes resulted in predictable and complete conversions of subtype-specific properties, i.e. dendrite orientation and matching axon projection pattern. Therefore, a combinatorial code of transcription during factors coordinates the development of dendrite and axon morphologies to generate anatomical specializations differentiating subtypes of T4/T5 motion-sensing neurons.

2020-04-02 | GSE147987 | GEO

Analysis of the developmental function of the PAIRED-Like homeobox transcription factor Drgx in T4/T5 neurons of Drosophila melanogaster [RNA-seq]

Project description:Analysis of the developmental function of the PAIRED-Like homeobox transcription factor Drgx in T4/T5 neurons of Drosophila melanogaster [RNA-seq]

| PRJNA1063784 | ENA

Translatome of developing drosophila t4/t5 neurons in wildtype versus atonal loss of function genotypes

Project description:Translatome of developing drosophila t4/t5 neurons in wildtype versus atonal loss of function genotypes

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Drosophila melanogaster

Project description:mRNA-seq of nuclear RNA extracted from T4 and T5 neurons of D. melanogaster

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Modular transcriptional programs separately define axon and dendrite connectivity

Project description:Patterns of synaptic connectivity are remarkably precise and complex. Single-cell RNA sequencing has revealed a vast transcriptional diversity of neurons. Nevertheless, a clear logic underlying the transcriptional control of neuronal connectivity has yet to emerge. Here, we focused on Drosophila T4/T5 neurons, a class of closely related neuronal subtypes with different wiring patterns. Eight subtypes of T4/T5 neurons are defined by combinations of two patterns of dendritic inputs and four patterns of axonal outputs. Single-cell profiling during development revealed distinct transcriptional programs defining each dendrite and axon wiring pattern. These programs were defined by the expression of a few transcription factors and different combinations of cell surface proteins. Gain and loss of function studies provide evidence for independent control of different wiring features. We propose that modular transcriptional programs for distinct wiring features are assembled in different combinations to generate diverse patterns of neuronal connectivity.

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