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Phenotypic Plasticity upon GSC Differentiation

ABSTRACT: At the cellular level, the malignant characteristics of GBM are largely attributed to GBM stem cells (GSCs). These cells, endowed with stem-like properties, can self-renew, generate diverse cancerous cell populations, and initiate tumors in vivo. The GSC lines, NCH644 and NCH421k, when cultured as neurospheres (NS) — a condition that preserves their stem-like state, as evidenced by the expression of stem cell markers like SOX2, CD133, and Nestin — were found to align with the PN subclass and CL-B/C respectively.

ORGANISM(S): Homo sapiens

PROVIDER: GSE253400 | GEO | 2024/02/13

REPOSITORIES: GEO

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