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Spatial multi-omics in skeletal muscle unravel complex myofiber architecture

ABSTRACT: Skeletal muscles are complex organs consisting of multiple tissues, including connective tissue, blood vessels, nerves and multinucleated myofibers. Single-nucleus transcriptomics analyses have revealed distinctive myonuclear populations related to myofiber type and to specialized regions, including neuromuscular and myotendinous junctions. However, the use of tissue dissociation methods prevented access to global spatial organization. Here we applied RNA tomography (TOMOseq), a spatial transcriptomics approach, to explore gene expression differences along murine tibialis anterior muscles.

ORGANISM(S): Mus musculus

PROVIDER: GSE253441 | GEO | 2024/09/19

REPOSITORIES: GEO

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Spatial multi-omics in skeletal muscle unravel complex myofiber architecture

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Spatial multi-omics in skeletal muscle unravel complex myofiber architecture

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