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FoxO transcription factors actuate the formative pluripotency specific gene expression programme

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE253480 | GEO | 2024/07/25

REPOSITORIES: GEO

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FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ChIP-Seq]

Project description:Naïve pluripotency is sustained by a self-reinforcing gene regulatory network (GRN) comprising core and naïve pluripotency-specific transcription factors (TFs). Upon exiting naïve pluripotency, ES cells transition through a formative post-implantation-like pluripotent state. However, the mechanisms underlying disengagement from the naïve GRN and initiation of the formative GRN remain unclear. Here, we demonstrate that phosphorylated AKT acts as a gatekeeper that prevents nuclear localization of FoxO TFs in naïve ESCs. PTEN-mediated reduction of AKT activity allows nuclear entry by FoxO TFs, enforcing a cell fate transition by binding and activating formative pluripotency-specific enhancers. Indeed, FoxO TFs are necessary and sufficient for transition from the naïve to the formative pluripotent state. Our work uncovers a pivotal role for FoxO TFs and AKT signalling in mechanisms underlying the exit from naïve pluripotency, a critical early embryonic cell fate transition.

2024-07-25 | GSE253479 | GEO

FoxO transcription factors actuate the formative pluripotency specific gene expression programme [RNA-Seq]

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FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ATAC-Seq]

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FoxO transcription factors actuate the formative pluripotency specific gene expression programme

Project description:FoxO transcription factors actuate the formative pluripotency specific gene expression programme

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FoxO transcription factors actuate the formative pluripotency specific gene expression programme [RNA-Seq]

Project description:FoxO transcription factors actuate the formative pluripotency specific gene expression programme [RNA-Seq]

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FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ATAC-Seq]

Project description:FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ATAC-Seq]

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FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ChIP-Seq]

Project description:FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ChIP-Seq]

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Three Transcription Factor Functions Empower Progression from Naïve to Formative Pluripotency

Project description:This SuperSeries is composed of the SubSeries listed below.

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Induction of pluripotency in mouse somatic cells with novel factors

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below.

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