Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE253480 | GEO | 2024/07/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ChIP-Seq]

Project description:Naïve pluripotency is sustained by a self-reinforcing gene regulatory network (GRN) comprising core and naïve pluripotency-specific transcription factors (TFs). Upon exiting naïve pluripotency, ES cells transition through a formative post-implantation-like pluripotent state. However, the mechanisms underlying disengagement from the naïve GRN and initiation of the formative GRN remain unclear. Here, we demonstrate that phosphorylated AKT acts as a gatekeeper that prevents nuclear localization of FoxO TFs in naïve ESCs. PTEN-mediated reduction of AKT activity allows nuclear entry by FoxO TFs, enforcing a cell fate transition by binding and activating formative pluripotency-specific enhancers. Indeed, FoxO TFs are necessary and sufficient for transition from the naïve to the formative pluripotent state. Our work uncovers a pivotal role for FoxO TFs and AKT signalling in mechanisms underlying the exit from naïve pluripotency, a critical early embryonic cell fate transition.

2024-07-25 | GSE253479 | GEO

FoxO transcription factors actuate the formative pluripotency specific gene expression programme [RNA-Seq]

2024-07-25 | GSE253473 | GEO

FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ATAC-Seq]

2024-07-25 | GSE253472 | GEO

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

Project description:FoxO transcription factors actuate the formative pluripotency specific gene expression programme

| PRJNA1065862 | ENA

FoxO transcription factors actuate the formative pluripotency specific gene expression programme [RNA-Seq]

Project description:FoxO transcription factors actuate the formative pluripotency specific gene expression programme [RNA-Seq]

| PRJNA1065870 | ENA

FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ChIP-Seq]

Project description:FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ChIP-Seq]

| PRJNA1065872 | ENA

FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ATAC-Seq]

Project description:FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ATAC-Seq]

| PRJNA1065871 | ENA

Three Transcription Factor Functions Empower Progression from Naïve to Formative Pluripotency

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-05-09 | GSE122338 | GEO

Induction of pluripotency in mouse somatic cells with novel factors

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-05-28 | E-GEOD-43995 | biostudies-arrayexpress

Capture of mouse and human stem cells with features of formative pluripotency

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-04 | GSE131556 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data