Transcriptomics

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Single-cell RNAseq datasets supporting the role of primary cilia to drive region-specific diversification of astrocytes within the developing brain


ABSTRACT: Astrocyte diversity is greatly influenced by local environmental modulation. In this study, we analyzed how primary ciliary signaling modulates astrocyte subtype-specific maturation and accessed the impact of ciliary deficient astrocytes on neuronal programs and behaviours. Comparative single-cell transcriptomics revealed that primary cilia mediate canonical Shh signaling to modulate astrocyte subtype-specific core features in synaptic regulation, intracellular transport, energy and metabolism. Our results uncover a critical role for primary cilia in transmitting local cues that drive the region-specific diversification of astrocytes within the developing brain.

ORGANISM(S): Mus musculus

PROVIDER: GSE253640 | GEO | 2024/01/24

REPOSITORIES: GEO

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