Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dynamic regulation of miRNA accumulation during C. elegans larval development [miRNA-Seq]

ABSTRACT: Here, we profile miRNA expression at high temporal resolution (1 hr interval) during C. elegans postembryonic development, which identifies several miRNAs with highly dynamic concentration changes

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE254319 | GEO | 2024/02/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Dynamic regulation of miRNA accumulation during C. elegans larval development [RNA-Seq]

Project description:Here, we profile miRNA expression at high temporal resolution (1 hr interval) during C. elegans postembryonic development, which identifies several miRNAs with highly dynamic concentration changes

2024-02-24 | GSE245892 | GEO

Dynamic regulation of miRNA accumulation during C. elegans larval development [smallRNA-Seq 4]

2024-02-24 | GSE245901 | GEO

Dynamic regulation of miRNA accumulation during C. elegans larval development [smallRNA-Seq 3]

2024-02-24 | GSE245900 | GEO

Dynamic regulation of miRNA accumulation during C. elegans larval development [smallRNA-Seq 2]

2024-02-24 | GSE245895 | GEO

Dynamic regulation of miRNA accumulation during C. elegans larval development [smallRNA-Seq 5]

Project description:Here, we profile miRNA expression at high temporal resolution (1 hr interval) from 5h to 48h at 25°C, during C. elegans postembryonic development, which identifies several miRNAs with highly dynamic concentration changes

2024-02-24 | GSE245902 | GEO

Dynamic regulation of miRNA accumulation during C. elegans larval development [smallRNA-Seq 1]

Project description:Here, we profile miRNA expression at high temporal resolution (1 hr interval) from 18h to 33h at 25°C, during C. briggsae postembryonic development, which identifies several miRNAs with highly dynamic concentration changes

2024-02-24 | GSE245894 | GEO

Dynamic regulation of miRNA accumulation during C. elegans larval development

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-02-22 | GSE245904 | GEO

Bacterial vitamin B6 is required for post-embryonic development in C. elegans

Project description:Nutritional intake influences animal growth, reproductive capacity, and survival of animals. Under nutrition deficiency, animal developmental arrest occurs as an adaptive strategy to survive. However, the nutritional basis and the underlying nutrient sensing mechanism essential for animal regrowth after developmental arrest remain to be explored. In Caenorhabditis elegans, larvae undergo early developmental arrest are stress resistant, and they require certain nutrients to recover postembryonic development. Here, we investigated the developmental arrest in C. elegans feeding on Lactiplantibacillus plantarum, and the rescue of the diapause state with trace supplementation of Escherichia coli. We performed a genome-wide screen using 3983 individual gene deletion E. coli mutants and identified E. coli genes that are indispensable for C. elegans larval growth on originally not nutritionally sufficient bacteria L. plantarum. Among these crucial genes, we confirmed E. coli pdxH, and the downstream metabolite pyridoxal 5-P (PLP, Vitamin B6) as important nutritional factors for C. elegans postembryonic development. Transcriptome results suggest that bacterial pdxH affects host development by coordinating host metabolic processes and PLP binding. Additionally, the developmental arrest induced by the L. plantarum diet in worm does not depend on the activation of FoxO/DAF-16. Altogether, these results highlight the role of microbial metabolite PLP as a crucial cofactor to restore postembryonic development in C. elegans.

2024-02-23 | GSE254343 | GEO

Proteomic characterisation of Caenorhabditis elegans larval development

Project description:The nematode Caenorhabditis elegans (C. elegans) is often used as a model organism to study cell and developmental biology. Quantitative mass spectrometry has only recently been performed in C. elegans and, so far, most studies have been done on adult worm samples. Here we use quantitative mass spectrometry to characterise protein level changes across the four larval developmental stages (L1-L4) of C. elegans, in biological triplicate. In total, we identify 4,130 proteins and quantify 1,541 proteins that were identified across all four stages in all three biological repeats with at least 2 unique peptides per protein. Using hierarchical clustering and functional ontological analyses, we identify 21 protein groups containing proteins with similar protein profiles across the four stages, and highlight the most overrepresented biological functions in each of these protein clusters. In addition, we use the dataset to identify putative larval stage specific proteins in each individual developmental stage, as well as in the early and late developmental stages. In summary, this dataset provides a system-wide analysis of protein level changes across the four C. elegans larval developmental stages, which serves as a useful resource for the worm development research community.

2017-12-04 | PXD006676 | Pride

Transcriptomic analysis of C. elegans infected with Myzocytiopsis humicola or treated with its extract

Project description:We used RNA-seq to identify gene expression changes in C. elegans after 1 hr, 4 hr, 12 hr and 24 hr of exposure to Myzocytiopsis humicola extract; and after 12 hr, 24 hr and 48 hr of infection with Myzocytiopsis humicola

2020-12-31 | GSE150135 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data