Transcriptomics

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Gene expression profile at single cell level of human pneumocytes and fibroblasts cultured as organoids


ABSTRACT: Alveolar type 2 (AT2) are part of the stem cell niche of the lung and their differentiation is required for pulmonary homeostasis and tissue regeneration. A disturbed crosstalk between fibroblasts and epithelial cells contributes to the loss of lung structure in chronic lung diseases. We used single cell RNA sequencing to analyze the interaction of human fibroblasts and the alveolar epithelium modelled in organoid cultures.

ORGANISM(S): Homo sapiens

PROVIDER: GSE254441 | GEO | 2024/02/19

REPOSITORIES: GEO

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