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ETMR stem-like state and chemoresistance are supported by perivascular cells at single-cell resolution

ABSTRACT: To investigate the cellular heterogeneity of ETMR and the role of pericytes in the tumor microenvironment, we performed sequencing at single-cell resolution of about 250,000 cells from primary human and murine ETMR as well as from 2D ETMR cultures and 3D models of ETMR-harboring forebrain organoids. We also analysed 3 ETMR human samples by spatial transcriptomics.

ORGANISM(S): Homo sapiens

PROVIDER: GSE254819 | GEO | 2025/04/17

REPOSITORIES: GEO

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