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Testis developmental gene expression in cryptorchid boys at risk of azoospermia

ABSTRACT: Despite timely and successful surgery, 32% of patients with bilateral and 10% with unilateral cryptorchidism will develop azoospermia. Cryptorchid boys at risk of azoospermia display a typical testicular histology of impaired mini-puberty at the time of the orchidopexy. During mini-puberty increased gonadotropin and testosterone secretion stimulate transformation of gonocytes into Ad spermatogonia. In azoospermia risk group this transformation is to a great extent impaired. This study aimed to analyze data on whole genome expression signatures of undescended testes at risk of developing azoospermia.

ORGANISM(S): Homo sapiens

PROVIDER: GSE25518 | GEO | 2010/11/23

SECONDARY ACCESSION(S): PRJNA133773

REPOSITORIES: GEO

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Transcription profiling of testis biopsies to investigate testis developmental gene expression in cryptorchid boys at risk of azoospermia

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