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Suppression of inflammaging prolongs hematopoietic healthspan [dataset 6]

ABSTRACT: The impact of recombinant Thbs1 (rThbs1) on HSC activity is unknown. In this experiment, RNA Seq analysis was performed on BM HSCs derived from young (4 month-old) control mice that were cultured ex vivo for 11 days in the presence rThbs1 (500 ng/mL) in the presence of a CD36 neutralizing antibody or its isotype control.

ORGANISM(S): Mus musculus

PROVIDER: GSE255655 | GEO | 2025/01/03

REPOSITORIES: GEO

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Suppression of inflammaging prolongs hematopoietic healthspan [dataset 2]

Project description:The impact of recombinant Thbs1 (rThbs1) on HSC activity is unknown. In this experiment, RNA Seq analysis was performed on BM HSCs derived from young (4 month-old) control mice that were cultured ex vivo for 11 days in the presence or absence of rThbs1 (500 ng/mL). Additionally, RNA Seq analysis of HSCs cultured with rThbs1 in the presence of its neutralizing antibody (Clone A4.1) or its isotype control was performed to identify the pathways that are altered in HSCs upon exposure to rThbs1.

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Suppression of inflammaging prolongs hematopoietic healthspan.

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-01-03 | GSE255656 | GEO