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Semimethylation is a feature of Diffuse Large B-cell Lymphoma, and subgroups with poor prognosis are characterized by global hypomethylation and short telomere length

ABSTRACT: We studied the DNA methylation profiles of 93 LBCL cases: Diffuse large B-cell lymphoma not otherwise specified (DLBCL, n=66), High-grade B-cell lymphoma (n=7), Primary CNS lymphoma (n=8), and transformation of indolent B-cell lymphoma (n=12). One sample of normal GC B-cells from tonsils was included as a control. LBCL cases had a particularly aberrant semimethylated pattern with large intertumor variation and overall low hypermethylation. In cases treated with R-CHOP-like regimens, a high percentage of global hypomethylation was independently associated with worse disease-specific survival and progression-free survival.

ORGANISM(S): Homo sapiens

PROVIDER: GSE255869 | GEO | 2024/05/20

REPOSITORIES: GEO

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