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Gene expression changes in response to tead degrader HC278

ABSTRACT: TEAD transcription factors associate with the hippo pathway effectors YAP/TAZ and mediate their oncogenic effect. To inhibit YAP activity, we developed a TEAD degrading PROTAC HC278. Here we treated NCI-H226 mesothelioma cells with DMSO or 500nM HC278 for 24 hours and examined the change in gene expression in response to HC278 treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE255974 | GEO | 2024/10/02

REPOSITORIES: GEO

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