Transcriptomics

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The disordered extensions of the Arid5a core ARID domain modulate its DNA- and RNA-binding propensities


ABSTRACT: ARID (AT-rich interacting domain) proteins are a heterogeneous family of DNA-binding proteins involved in transcriptional regulation. No precise DNA-binding preferences have yet been defined for the aberrant member Arid5a. In addition, the protein binds to mRNA motifs for transcript stabilisation, presumably through the DNA-binding ARID domain. Here we first provide an unbiased definition of RNA motifs and a clear breakdown of nucleic acid binding by the ARID domain. An RNA Bind-n-Seq (RBNS) experiment was performed to find a consensus motif of the Arid5a domain. It reveals a preference for an unexpected CAGGCAG consensus motif, accompanied by a general preference for AU-rich motifs.

ORGANISM(S): synthetic construct

PROVIDER: GSE256029 | GEO | 2024/03/21

REPOSITORIES: GEO

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