Genomics

Dataset Information

0

DNA damage hotspots for the Top2i "ICRF193"


ABSTRACT: In our project we are using the Top2 inhibitor, ICRF-193, in order to induce damage in NIH3T3 MEFs. We report the high-throughput identification of genomic hotspots for damage induction by ICRF-193, using γH2AX as a marker. We find that ICRF-193 primarily induces damage in repetitive sequences, which are known to reside in regions of heterochromatin, with a very small portion of damaged sites residing in regions of active genes in euchromatin. Overall, this study provides evidence that catalytic inhibition of Top2 enzymes by ICRF-193, leads to induction of damage in the nuclear sub-compartments of heterochromatin.

ORGANISM(S): Mus musculus

PROVIDER: GSE256090 | GEO | 2024/04/17

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-04-09 | GSE148303 | GEO
2022-08-18 | GSE190735 | GEO
2017-03-01 | GSE94039 | GEO
| PRJNA1078073 | ENA
2017-02-13 | GSE80682 | GEO
2021-12-02 | GSE178684 | GEO
2014-04-17 | E-GEOD-56872 | biostudies-arrayexpress
2021-12-31 | GSE181934 | GEO
2012-12-26 | GSE43121 | GEO
2012-12-26 | GSE43118 | GEO