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Genome-wide analysis of gene expression in Eµ-Myc and Eµ-Myc Wrn Δhel/Δhel murine lymphomas

ABSTRACT: Transcriptional profiling Myc-driven lymphomas to determine pathways by which Wrn deficiency impairs tumor development

ORGANISM(S): Mus musculus

PROVIDER: GSE25671 | GEO | 2012/02/25

SECONDARY ACCESSION(S): PRJNA134213

REPOSITORIES: GEO

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Genome-wide analysis of gene expression in Eµ-Myc and Eµ-Myc Wrn Δhel/Δhel murine lymphomas

Project description:Transcriptional profiling Myc-driven lymphomas to determine pathways by which Wrn deficiency impairs tumor development Total RNA isolated from Eµ-Myc and Eµ-Myc Wrn Δhel/Δhel murine B-cell lymphomas (n=4)

2012-02-25 | E-GEOD-25671 | biostudies-arrayexpress

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Transgenic Eµ-myc mouse lymphoma expression data for training dataset

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Transgenic Eµ-myc mouse lymphoma expression data for training dataset

Project description:We used gene expression data from Eµ-myc mouse lymphomas to perform unsupervised analyses that identified two lymphoma subgroups. We also used this data to develop a genomic signature to classify new lymphomas. When Eµ-myc mice had evidence of lymphoma and/or ill appearance, they were humanely sacrificed and dissected. Lymphoma tissue was obtained and flash frozen in liquid nitrogen. Later, lymphoma tissue was homogenized, and RNA was extracted. Gene expression microarrays were performed with the isolated RNA.

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