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Interleukin-10 expression in the mouse spleen in the LPS-induced model

ABSTRACT: In the LPS-induced innate immune response, the expression level of IL-10 in the spleen of mice was significantly increased. The expression of this key anti-inflammatory cytokine is regulated by local sympathetic projections; however, the cell type in which it is expressed is unknown. Therefore, in this study, we used the LPS-induced mouse spleen model to analyze the spatial transcriptome, and found that IL10+ cells were mainly B cells. In addition, single-cell sequencing analysis of B cells isolated from the spleen of mice also showed that they expressed IL10. These results collectively suggest that B cells are the predominant cell type expressing IL10 in mouse spleen.

ORGANISM(S): Mus musculus

PROVIDER: GSE259292 | GEO | 2025/02/26

REPOSITORIES: GEO

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