Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription factor overexpression in HeLa cell lines

ABSTRACT: Experiments measuring effects of overexpression of the transcription factors RUNX1 and CBF-beta (in combination), and TELRUNX1 (fusion protein of TEL and RUNX1). Overexpression is achieved via adenovirus infection of HeLa cell lines. Keywords: other

ORGANISM(S): Homo sapiens

PROVIDER: GSE2593 | GEO | 2005/12/01

SECONDARY ACCESSION(S): PRJNA92001

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcription factor overexpression in HeLa cell lines

Project description:Experiments measuring effects of overexpression of the transcription factors RUNX1 and CBF-beta (in combination), and TELRUNX1 (fusion protein of TEL and RUNX1). Overexpression is achieved via adenovirus infection of HeLa cell lines.

2005-11-30 | E-GEOD-2593 | biostudies-arrayexpress

HeLa Adenovirus timecourse

Project description:HeLa Adenovirus timecourse

| PRJEB3253 | ENA

HeLa, ZBTB2-myc overexpression, 0.1% O2

Project description:HeLa, ZBTB2-myc overexpression, 0.1% O2

| PRJNA928321 | ENA

EGR1 overexpression in HeLa cells [EGR1oe_RNAseq]

Project description:EGR1 overexpression in HeLa cells [EGR1oe_RNAseq]

| PRJNA862895 | ENA

HeLa Adenovirus timecourse

Project description:A timecourse of adenovirus infection of human HeLa cells, using RNA-seq

2012-10-27 | E-MTAB-1277 | biostudies-arrayexpress

RNA-seq of human HeLa cell

Project description:To study the effects of overexpression CD38 in Hela cell

2016-09-07 | GSE85227 | GEO

A compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes

Project description:Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of RUNX1 target genes. Here, through genome-wide CBF-MYH11 binding site analysis and quantitative interaction proteomics we found that CBF-MYH11 localizes to RUNX1 occupied promoters where it interacts with TAL1, FLI1 and TBP associated factors (TAFs) in the context of the hematopoietic transcription factors ERG, GATA2 and PU.1/SPI1 and the co regulators EP300 and HDAC1. Transcriptional analysis revealed that upon fusion protein knock down a subset of the CBF-MYH11 target genes show increased expression, confirming a role in transcriptional repression. However, the majority of CBF-MYH11 target genes, including genes implicated in hematopoietic stem cell (HSC) self-renewal such as ID1, LMO1 and JAG1, are actively transcribed and upon fusion protein knock down repressed. Together these results suggest an essential role for CBF-MYH11 in regulating expression of genes involved in maintaining a stem cell phenotype.

2013-09-09 | GSE46044 | GEO

HeLa, ZBTB2-myc overexpression, 0.1% O2

Project description:In order to identify candidate genes regulated by ZBTB2 under hypoxia, we examined the genomic occupancy of myc-tagged ZBTB2 in HeLa cells incubated under 0.1% oxygen.

2023-06-08 | GSE223754 | GEO

Expression data from hela cells stable clones overexpressing TFEB-GFP

Project description:In order to identify the effects of TFEB overexpression on the hela cells transcriptome, we performed Affymetrix Gene-Chip hybridization experiments for the hela TFEB stable clones Transcriptome analysis of hela stable clones overexpressing TFEB-GFP

2018-09-07 | GSE73055 | GEO

Expression data from hela cells stable clones overexpressing TFEB-3xFLAG

2021-07-06 | GSE73054 | GEO