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Bzip9-Energetic Homeostasis and Sugar Signaling

ABSTRACT: bra-inra09-01_bioen - bzip9 - Diversification of the Molecular Mechanisms Involved in the Control of the Energetic Balance in Angiosperms - To elucidate the role of selected bZIP transcription factors (AtbZIP3, AtbZIP9, AtbZIP63; the expression of these genes is repressed by glucose and are poorly characterized) involved in glucose-triggered transcriptional cascade, the target genes of these bZIP TF will be identified. The glucose-mediated regulations of these bZIP genes will be investigated by identifying the cis-regulatory sequences and the upstream regulatory factors. The functional conservation of the corresponding bZIP orthologues in sugar cane and rice will be evaluated.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE26041 | GEO | 2012/01/01

SECONDARY ACCESSION(S): PRJNA135533

REPOSITORIES: GEO

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bzip9-Energetic Homeostasis and Sugar Signaling

Project description:bra-inra09-01_bioen - bzip9 - Diversification of the Molecular Mechanisms Involved in the Control of the Energetic Balance in Angiosperms - To elucidate the role of selected bZIP transcription factors (AtbZIP3, AtbZIP9, AtbZIP63; the expression of these genes is repressed by glucose and are poorly characterized) involved in glucose-triggered transcriptional cascade, the target genes of these bZIP TF will be identified. The glucose-mediated regulations of these bZIP genes will be investigated by identifying the cis-regulatory sequences and the upstream regulatory factors. The functional conservation of the corresponding bZIP orthologues in sugar cane and rice will be evaluated. 12 dye-swap - genotype comparison

2012-01-01 | E-GEOD-26041 | biostudies-arrayexpress

abi4-Energetic Homeostasis and Sugar Signaling

Project description:bra-inra09-01_bioen - abi4 - Diversification of the Molecular Mechanisms Involved in the Control of the Energetic Balance in Angiosperms - Abi4 is regulator pleotropic that interview in the metabolism glucose

2012-01-01 | GSE26044 | GEO

abi4-Energetic Homeostasis and Sugar Signaling

2012-01-01 | E-GEOD-26044 | biostudies-arrayexpress

cordycepin-Energetic Homeostasis and Sugar Signaling

Project description:bra-inra09-01_bioen - cordycepin - Diversification of the Molecular Mechanisms Involved in the Control of the Energetic Balance in Angiosperms - To evaluate the importance of mRNA stability control in glucose signaling, genome wide RNA transcript levels changes will be evaluated in response to short term treatments with glucose or glucose plus abscisic acid (ABA) under conditions of transcriptional inhibition in Arabidopsis. The underlying mechanisms will be investigated for a selected number of co-regulated genes (transcription factors, kinases). 12 dye-swap - treatment variations

2012-01-01 | E-GEOD-26045 | biostudies-arrayexpress

cordycepin-Energetic Homeostasis and Sugar Signaling

2012-01-01 | GSE26045 | GEO

Conservation and divergence of small RNA pathways in vascular plants revealed by small RNA analyses in lycophytes and ferns

Project description:Pathways underlying miRNA biogenesis, degradation, and activity were established early in land plant evolution, but the 24-nt siRNA pathway that guides DNA methylation was incomplete in early land plants, especially lycophytes. We show that the functional diversification of key gene families such as DICER-LIKE and ARGONAUTE (AGO) as observed in angiosperms occurred early in land plants followed by parallel expansion of the AGO family in ferns and angiosperms. We uncovered an unexpected AGO family specific to lycophytes and ferns. Our phylogenetic analyses of miRNAs in lycophytes, bryophytes, ferns, and angiosperms refined the temporal origination of conserved miRNA families in land plants.

2017-07-20 | GSE98408 | GEO

MYC sensitises cells to apoptosis by driving energetic demand

Project description:The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces several biosynthetic programmes and primary cells overexpressing MYC are highly sensitive to glutamine withdrawal suggesting that MYC-induced sensitisation to apoptosis may be due to an imbalance of metabolic/energetic supply and demand. Here we show that MYC elevates global transcription and translation, even in the absence of glutamine, revealing metabolic demand without corresponding supply. Glutamine withdrawal from MRC-5 fibroblasts depleted key TCA cycle metabolites and, in combination with MYC activation, led to AMP accumulation and nucleotide catabolism indicative of energetic stress. Further analyses revealed that glutamine supports viability through TCA cycle energetics rather than asparagine biosynthesis and that TCA cycle inhibition confers tumour suppression on MYC- driven lymphoma in vivo. In summary, glutamine supports the viability of MYC- overexpressing cells through an energetic rather than a biosynthetic mechanism.

2022-08-11 | PXD034517 | Pride

Intrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model

Project description:Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in the fetal adaptive mechanism to IUGR given its high energetic demands. The energetic homeostasis depends on the correct interaction of several molecular pathways and the adequate arrangement of intracellular energetic units (ICEUs), where mitochondria interact with the contractile machinery and the main cardiac ATPases to enable a quick and efficient energy transfer. We studied subcellular cardiac adaptations to IUGR in an experimental rabbit model. We evaluated the ultrastructure of ICEUs with transmission electron microscopy and observed an altered spatial arrangement in IUGR, with significant increases in cytosolic space between mitochondria and myofilaments. A global decrease of mitochondrial density was also observed. In addition, we conducted a global gene expression profile by advanced bioinformatics tools to assess the expression of genes involved in the cardiomyocyte energetic metabolism, and identified four gene modules with a coordinated over-representation in IUGR: oxygen homeostasis (GO: 0032364), mitochondrial respiratory chain complex I (GO:0005747), oxidative phosphorylation (GO: 0006119) and NADH dehydrogenase activity (GO:0003954). These findings might contribute to changes in energetic homeostasis in IUGR. The potential persistence and role of these changes in long term cardiovascular programming deserves further investigation. In this study, we used gene expression arrays to investigate differences between two experimental groups: IUGR and control. The design includes paired samples.

2013-10-30 | E-GEOD-37860 | biostudies-arrayexpress

Intrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model

2013-10-30 | GSE37860 | GEO

Mitochondrial energetic stress triggers AMPK/FNIP1-dependent TFEB nuclear translocation, inducing transcriptional waves of lysosomal and mitochondrial biogenesis.

Project description:Cells respond to mitochondrial energetic stress with rapid activation of the AMP-activated protein kinase (AMPK), which acutely inhibits anabolism and stimulates catabolism. AMPK also induces sustained transcriptional reprogramming of metabolism. The TFEB transcription factor is a major effector of AMPK signals, inducing lysosome genes following energetic stress. Yet the molecular mechanism underlying how AMPK activates TFEB remains unresolved. We demonstrate here that AMPK directly phosphorylates five conserved serine residues in FNIP1, which suppresses the function of the FLCN/FNIP1 RagC GAP complex, in turn controlling TFEB lysosomal localization. We demonstrate that FNIP1 phosphorylation is required for AMPK to induce nuclear translocation of TFEB, which is fully separable from AMPK control of canonical mTORC1 signaling. Using a non-phosphorylatable allele of FNIP1, we show that in parallel to lysosomal biogenesis, AMPK induces mitochondrial biogenesis via TFEB-dependent induction of PGC1a mRNA. This signaling from mitochondrial stress is also independent of amino-acid control of the Rags and TFEB, which still proceed normally in cells bearing the AMPK-non phosphorylatable allele of FNIP1. Taken together, mitochondrial energetic stress triggers AMPK/FNIP1-dependent TFEB nuclear translocation, inducing transcriptional waves of lysosomal and mitochondrial biogenesis.

2023-05-08 | GSE218827 | GEO

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