Transcriptomics

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Cytoplasmic Accumulation of Incompletely Glycosylated Sex Hormone-binding Globulin (SHBG) Enhances Androgen Action in Proximal Convoluted Tubule Epithelial Cells


ABSTRACT: Identification of androgen-responsive genes that are influenced by the presence of a functional SHBG versus a steroid-binding-deficient SHBG mutant (SHBG S42L) in the cytoplasm of PCT cells. The hypothesis tested in the study was that SHBG enhances androgen action. Results provide important information that intracellular SHBG enhances androgen-dependent stimulation or repression in PCT cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE26058 | GEO | 2010/12/15

SECONDARY ACCESSION(S): PRJNA135567

REPOSITORIES: GEO

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