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Definition of cortical somatosensory maps is fine-tuned by prenatal thalamic spontaneous activity

ABSTRACT: The brain's sensory representation relies on precise mapping of peripheral inputs onto cortical areas. In the mouse primary somatosensory cortex, prominent mystacial whiskers are represented in large, conspicuous barrels, while the smaller upper lip whiskers are represented by numerous smaller barrels. Traditionally, barrel area size is believed to be determined postnatally by whisker input and receptor density. However, prenatal thalamic spontaneous activity can influence cortical barrel size independently of whisker input. Thus, the developmental mechanisms defining distinct barrel field territories, including size and map definition, remain poorly understood. Here, we show that prenatal ablation of mystacial whiskers enhances the functional and anatomical definition of upper lip whisker barrels without affecting receptors density. These changes result from prenatal alterations in thalamic spontaneous activity patterns involving specific transcriptional modifications, highlighting the significance of prenatal synchronized neuronal activity in shaping cortical barrel size and functional map definition in the developing somatosensory system.

ORGANISM(S): Mus musculus

PROVIDER: GSE260865 | GEO | 2024/12/20

REPOSITORIES: GEO

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