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Single-cell 3D genome structure reveals distinct human pluripotent states

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE260995 | GEO | 2024/03/11

REPOSITORIES: GEO

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Single-cell 3D genome structure reveals distinct human pluripotent states (RNA-Seq)

Project description:Pluripotent states of embryonic stem cells (ESCs) with distinct transcription profile affect their differentiation capacity and therapeutic potential. By single cell analysis of high-resolution three-dimensional (3D) genome structure, we show that remodeling genome structure is highly associated with pluripotent states of human ESCs (hESCs). Naive pluripotent state is featured with specialized 3D genome structures and clear chromatin compartmentation distinct from primed state. Naive pluripotent state may be achieved by remodeled active euchromatin compartment and less chromatin interaction in the nuclear center. This unique genome organization is linked to elevated chromatin accessibility on enhancers and thus high expression levels of naive pluripotent genes localized in this region. On the contrary, primed state exhibits intermingled genome organization. Moreover, active euchromatin and primed pluripotent genes are distributed in the nuclear periphery and yet repressive heterochromatin densely concentrated in the nuclear center, reducing chromatin accessibility and transcription of naive genes. Thus, inversion or relocation of heterochromatin to euchromatin compartmentation is related to regulating chromatin accessibility and thus define pluripotent states and cell identity.

2024-03-11 | GSE260994 | GEO

Single-cell 3D genome structure reveals distinct human pluripotent states (ATAC-Seq)

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Single-cell 3D genome structure reveals distinct human pluripotent states

Project description:Single-cell 3D genome structure reveals distinct human pluripotent states

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Single-cell 3D genome structure reveals distinct human pluripotent states (RNA-Seq)

Project description:Single-cell 3D genome structure reveals distinct human pluripotent states (RNA-Seq)

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Single-cell 3D genome structure reveals distinct human pluripotent states (ATAC-Seq)

Project description:Single-cell 3D genome structure reveals distinct human pluripotent states (ATAC-Seq)

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Project description:Single-cell 3D genome structure reveals distinct human pluripotent states (CUT&Tag-seq)

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Epigenomic comparison of distinct pluripotent stem cell states reveals a new class of enhancers with roles throughout mammalian development

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic Hierarchy

Project description:This SuperSeries is composed of the SubSeries listed below.

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