Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MicroRNA profiling in PBMCs of patients at risk for mood disorders

ABSTRACT: microRNAs are a large class of small regulatory non-coding RNAs that play important roles in nervous system development and plasticity. Differential microRNA expression in peripheral blood mononuclear cells (PBMCs) has been observed in different neurological disorders and could potentially be used for diagnostic purposes and disease classification.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261287 | GEO | 2024/03/18

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Shared Molecules

Only show the datasets with similarity scores above: 0.5

Threshold

0.5

Similar Datasets

microRNA profiling in PBMCs of patients at risk for mood disorders

Project description:microRNA profiling in PBMCs of patients at risk for mood disorders

| PRJNA1086401 | ENA

Sen2020 - Metabolic alteration in PBMCs associated with type 1 diabetes

Project description:Genome-Scale draft model for Human Peripheral Blood Mononuclear Cells (PBMCs). A GEM for PBMCs was developed by applying the INIT algorithm on Human Metabolic Reconstruction (HMR 2.0) as a template model. GEMs were contextualised/ constrained for different conditions using expression datasets. The gene/transcript expression data obtained from PBMCs of Type 1 Diabetes progressors, non-progressors, and healthy controls were employed to score each reaction of HMR 2.0. For further detail please refer to Electronic Supplementary Information of Sen et.al, Metabolic alterations in immune cells associate with progression to type 1 diabetes, Diabetologia, 15/01/2020, (https://doi.org/10.1007/s00125-020-05107-6).

2020-03-11 | MODEL1905270001 | BioModels

Differential Gene Expression in Patients with Mood Disorders

Project description:RNA was extracted from peripheral blood mononuclear cells (PBMC) of 24 adult healthy controls, 8 adult patients with bipolar disorder, and 21 adult patients with major depressive disorder to analyze gene expression patterns that identify biomarkers of disease and that may be correlated with fMRI data.

2012-07-26 | GSE39653 | GEO

Protein expression of PBMCs treated with ITPRIPL1

Project description:Purified human ITPRIPL1-extracellular domain (ITPRIPL1-ECD) protein or PBS was added to human peripheral blood mononuclear cells (PBMCs) as a widely used source of immune cells and treated for 18 hours under 37℃, 5% CO2 in separate 1.5 ml EP tubes (n=3 independent samples for each condition)

2024-03-10 | PXD050518 |

PBMCs from healthy volunteers or septic patients

Project description:This study aimed to analyze and compare the test transcripts of peripheral blood mononuclear cells (PBMCs) isolated from 4 healthy donors and 4 septic patients' whole blood.

2024-08-15 | GSE241238 | GEO

Mild, moderate and severe enterovirus 71 (EV71) isolates infection in human PBMCs

Project description:Hand, foot and mouth disease (HFMD), caused by enterovirus 71 (EV71), presents mild to severe disease, and sometimes fatal neurological and respiratory manifestations. However, reasons for the severe pathogenesis remain undefined. To investigate this, infection and viral kinetics of EV71 isolates from clinical disease (mild, moderate and severe) from Sarawak, Malaysia, were characterized in human rhabdomyosarcoma (RD), neuroblastoma (SH-SY5Y) and peripheral blood mononuclear cells (PBMCs). High resolution transcriptomics was used to decipher EV71-host interactions in PBMCs. Ingenuity analyses revealed similar pathways triggered by all EV71 isolates, although the extent of activation varied. Importantly, several pathways were found to be specific to the severe isolate, including triggering receptor expressed on myeloid cells 1 (TREM-1) signaling. Depletion of TREM-1 in EV71-infected PBMCs with peptide LP17 resulted in decreased levels of pro-inflammatory genes, and reduced viral loads for the moderate and severe isolates. Mechanistically, this is the first report describing the transcriptome profiles during EV71 infections in primary human cells, and the involvement of TREM-1 in the severe disease pathogenesis, thus providing new insights for future treatment targets.

2020-03-16 | GSE135964 | GEO

Single-cell sequencing of PBMCs from myasthenia crisis patients

Project description:This project contains pre-processed single-cell sequencing data of the human peripheral blood mononuclear cells (PBMCs) from three myasthenia crisis patinets.

2023-01-13 | GSE222427 | GEO

miR from peripheral blood mononuclear cells' (PBMCs') exosome

Project description:miR from peripheral blood mononuclear cells' (PBMCs') exosome

| PRJNA786954 | ENA

Allergic contact dermatitis to nickel is characterized by a specific microRNA signature [PBMCs]

Project description:We found that peripheral blood mononuclear cells (PBMCs) (from subjects with allergy to nickel) stimulated with nickel were characterized by a specific miRNA signature that were different from vehicle-stimulated PBMCs.

2015-10-01 | GSE58815 | GEO

Expression profiling of PBMCs from patients with systemic lupus erythematosus

Project description:Aberrant gene expression analysis between peripheral blood mononuclear cells (PBMCs) samples from healthy controls (HC) and patients with systemic lupus erythmatosus (SLE) were identified using Affymetrix gene arrays

2020-01-29 | GSE144390 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data