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Direct measurement of RNA Polymerase II hypertranscription in cancer FFPE samples

ABSTRACT: Hypertranscription occurs at targets of oncogene transcription factors in aggressive human cancers. However, detection relies on mRNAs which are heavily processed and have variable half-lives, and on accurate cell number estimations. Here we apply FFPE-CUTAC on slides and curls to quantify hypertranscription at regulatory elements and replication-coupled histone genes.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE261351 | GEO | 2025/01/16

REPOSITORIES: GEO

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