Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Time course gene expression pattern during neural crest cell (NCC) differentiation from induced pluripotent stem cells (iPSCs) in three-dimensional (3D) conditions

ABSTRACT: To clarify the changes in cell properties during the differentiation process from iPSCs into NCC aggregates, we sampled iPSCs and each cell aggregate during the differentiation process and compared gene expression patterns.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261638 | GEO | 2025/03/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Generation of mandibular prominence ectomesenchyme (mdEM) from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates

Project description:To clarify the changes in cell properties during the differentiation process from iPSCs into mdEM through NCC aggregates, we sampled iPSCs and cell aggregates during the differentiation process and compared gene expression patterns.

2025-03-31 | GSE261851 | GEO

Induction of osteogenic lineage cells from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates through mandibular prominence ectomesecnhyme (mdEM)

Project description:To clarify the changes in cell properties during the differentiation process from iPSC-derived NCC aggregates into osteogenic cells through mdEM, we sampled cell aggregates during the differentiation and compared gene expression patterns.

2025-03-31 | GSE261738 | GEO

The expression of regional markers in neural crest cell (NCC) aggregates treated with or without retinoic acid (RA).

Project description:To evaluate the anterior-posterior axial identity of the NCC aggregates, we prepared aggregates treated with RA to induce posterior fates as a positive control and compared gene expression patterns among the aggregates.

2025-03-31 | GSE261639 | GEO

Time course expression pattern during neural crest cells (NCCs) differentiation from iPSCs

Project description:To clarify the changes in cell properties during the differentiation process from iPSCs into NCCs, we sampled each cell during the differentiation process and compared gene expression patterns.

2022-06-18 | GSE206048 | GEO

Spontaneous induction of neural crest cells in human pluripotent stem cell-derived aggregates revealed by single-cell RNA sequencing

Project description:Neural crest cells (NCCs) are a transient population which contributes to the majority of craniofacial tissue. The development of craniofacial tissue involves highly complex intermingled processes of cell fate specification and migration in densely packed mesenchyme. The establishment of appropriate in vitro models would be helpful for understanding these complicated processes. Thus, we developed a new method to induce NCCs in aggregates of human pluripotent stem cells (hPSCs). To gain insight into the process of aggregate development we performed single cell RNA sequencing (scRNA-seq) on day 2, 3, 4, and 5. scRNA-seq analysis revealed that hPSCs in the aggregates acquired neural plate border NPB-like identity before NCC induction. scRNA-seq also revealed that NCCs showed changes in the gene expression associated with epithelial mesenchymal transition as in vivo developmental process.

2024-01-03 | GSE199158 | GEO

Time course gene expression pattern during neural crest cell (NCC) differentiation from induced pluripotent stem cells (iPSCs) in three-dimensional (3D) conditions

Project description:Time course gene expression pattern during neural crest cell (NCC) differentiation from induced pluripotent stem cells (iPSCs) in three-dimensional (3D) conditions

| PRJNA1088147 | ENA

Expression data from neural crest cells and neural crest cell-derived MSCs from human pluripotent stem cells of FOP patients and controls

Project description:NCCs and NCC-derived MSCs were induced from FOP-iPSCs and control iPSCs, and their expresion profiles were compared. Comparison of gene expressions among hiPSCs, hESCs, hNCCs and hNC-MSCs from FOP-iPSCs and control-iPSCs.

2015-09-17 | E-GEOD-61510 | biostudies-arrayexpress

Expression data from neural crest cells and neural crest cell-derived MSCs from human pluripotent stem cells of FOP patients and controls

Project description:NCCs and NCC-derived MSCs were induced from FOP-iPSCs and control iPSCs, and their expresion profiles were compared.

2015-09-17 | GSE61510 | GEO

Generation of mesenchymal stem/stromal cells (MSCs) from human iPSCs via neural crest cells (NCCs)

Project description:To clarify the changes in cell properties during the differentiation process from iPSCs into MSC through NCCs, we sampled each cell during the differentiation process and compared gene expression patterns.

2022-06-19 | GSE206128 | GEO

The expression of regional markers in neural crest cell (NCC) aggregates treated with or without retinoic acid (RA).

Project description:The expression of regional markers in neural crest cell (NCC) aggregates treated with or without retinoic acid (RA).

| PRJNA1088146 | ENA