Transcriptomics

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Single-cell multiomics reveals stage of differentiation and trajectory-dependent immunity-related gene expression patterns in human erythroid cells


ABSTRACT: Erythroid cells, serving as progenitors and precursors to erythrocytes responsible for oxygen transport, exhibit a notable immunosuppressive and immunoregulatory phenotype. The present study CITE-seq reveals that erythroid cells have stage of differentiation-dependent immunity-related gene expression patterns. We also found that Erythroid cell differentiation is not linear and there is a bifurcation of polychromatophilic erythroblasts into ARG1 expressing polychromatophilic erythroblasts and orthochromatophilic erythroblasts. ARG1 expressing polychromatophilic erythroblasts account for almost all immunosuppressive ARG1 gene expression among erythroid cells. Thus, we infer the stepwise erythroid cells differentiation trajectory that has a branch that forms immunosuppressive erythroid cell population.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261733 | GEO | 2024/03/20

REPOSITORIES: GEO

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