Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Recapitulation of regional patterning using human induced pluripotent stem cell (iPSC)-derived mandibular prominence ectomesecnhyme (mdEM)

ABSTRACT: To ascertain the induction of developmentally accurate mdEM, we sampled cell aggregates during regional patterning induction and compared gene expression patterns.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261849 | GEO | 2025/03/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Generation of mandibular prominence ectomesenchyme (mdEM) from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates

Project description:To clarify the changes in cell properties during the differentiation process from iPSCs into mdEM through NCC aggregates, we sampled iPSCs and cell aggregates during the differentiation process and compared gene expression patterns.

2025-03-31 | GSE261851 | GEO

Induction of osteogenic lineage cells from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates through mandibular prominence ectomesecnhyme (mdEM)

Project description:To clarify the changes in cell properties during the differentiation process from iPSC-derived NCC aggregates into osteogenic cells through mdEM, we sampled cell aggregates during the differentiation and compared gene expression patterns.

2025-03-31 | GSE261738 | GEO

Regulatory elements in a Transcriptional Network Orchestrating Regional Patterning of Cortical Progenitors

Project description:To map enhancers involved in regional patterning of cortical progenitors, we performed TF ChIP for patterning transcription factors as well as assays for epigenomic marks and DNA accessibility in VZ cells purified from wild-type and patterning mutant mice. This integrated approach identified a cortical Regionalization TF network and VZ enhancers involved in cortical regional patterning.

2021-09-07 | GSE183130 | GEO

Otx2 controls regional patterning within the MGE and regional identity of the septum [ChIP-Seq]

Project description:The Otx2 homeobox transcription factor is essential for gastrulation and early neural development. We generated Otx2 conditional knockout (cKO) mice to investigate its roles in telencephalon development after E9.0. We conducted transcriptional profiling and in situ hybridization to identify genes de-regulated in Otx2 cKO ventral forebrain. In parallel, we used ChIP-seq to identify enhancer elements, OTX2 binding motif, and which de-regulated genes are likely direct targets of Otx2 transcriptional regulation. We found that Otx2 was essential in septum specification; regulation of Fgf signaling in the rostral telencephalon; and medial ganglionic eminence (MGE) patterning, neurogenesis, and oligodendrogenesis. Within the MGE, Otx2 was required for ventral but not dorsal identity; this is the first demonstration of a transcription factor that contributes to regional patterning within the MGE. Microdissected subpallium (septum, MGE, and LGE ) from wildtype E12.5 CD-1 embryos was used in three independentanti-OTX2 ChIP-seq experiments.

2015-06-10 | E-GEOD-69724 | biostudies-arrayexpress

Otx2 controls regional patterning within the MGE and regional identity of the septum [Agilent]

2015-06-03 | GSE69547 | GEO

Otx2 controls regional patterning within the MGE and regional identity of the septum [ChIP-Seq]

2015-06-10 | GSE69724 | GEO

Regional Immune Response to Trichostrongylis colubriformis in Sheep

Project description:This SuperSeries is composed of the following subset Series: GSE23859: Regional Immune Response to Trichostrongylis colubriformis - Gene Expression during the Development of Immunity GSE23863: Regional Immune Response to Trichostrongylis colubriformis - Gene Expression during Challenge of Immunized Sheep Refer to individual Series

2010-09-01 | E-GEOD-23890 | biostudies-arrayexpress

Methylome remodeling in regional breast cancer metastasis [expression]

Project description:We sought to characterize methylome remodeling during regional metastasis. We profiled the DNA methylome (n=44) and transcriptome (n=36) of matched primary breast tumors and regional metastases.

2014-12-01 | GSE57968 | GEO

Regional Proteomics in rTg-DI Rats

Project description:This project utilized UPLC TripleTOF MS/MS and data independent acquisition (DIA), and spectral analysis in Spectronaut (Biognosys) to study brain regional proteomic changes in a cerebral amyloid angiopathy pre-clinical model, rTg-DI. Results revealed similar and regionally distinct differentially expressed proteins in rTg-DI rats.

2020-11-10 | MSV000086432 | MassIVE

HAND2 regulates regional chromation modification [HAND2-knockdown_histone_ChIPseq]

Project description:The knockdown of HAND2 affects the regional chromation modification.

2023-03-29 | GSE184058 | GEO