Transcriptomics

Dataset Information

0

Interleukin-17 directly stimulates tumor infiltrating Tregs to prevent cancer development [bulk RNA-seq]


ABSTRACT: Interleukin-17 (IL-17) family cytokines promote protective inflammation for pathogen resistance, but also facilitate autoimmunity and tumor development. A direct signal of IL-17 to regulatory T cells (Tregs) has not been reported and may help explain these dichotomous responses. Here we show in mice that IL-17 Receptor A (IL-17RA) is expressed in Tregs that reside in mouse mesenteric lymph nodes and colon tumors, as well as in patients with colorectal cancer (CRC). Ablation of IL-17RA, specifically in Tregs, resulted in increased Th17 cells, and exacerbated tumor development. Mechanistically, tumor-infiltrating Tregs exhibit a unique gene signature that is linked to their activation, maturation, and suppression function, and this signature is in part supported by the direct signaling of IL-17 to Tregs. To study pathways of Treg programming, we found that loss of IL-17RA in tumor Tregs resulted in reduced RNA splicing, and downregulation of several RNA binding proteins that are known to regulate alternative splicing and promote Treg function. Taken together, we report a direct role of IL-17 in promoting Treg maturation and function in CRC.

ORGANISM(S): Mus musculus

PROVIDER: GSE262402 | GEO | 2024/06/14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-06-14 | GSE262405 | GEO
2015-08-20 | GSE72212 | GEO
2024-02-28 | GSE240707 | GEO
2021-12-22 | GSE173124 | GEO
2019-02-01 | GSE121883 | GEO
2024-04-15 | GSE264054 | GEO
2015-05-19 | E-GEOD-68991 | biostudies-arrayexpress
2015-11-01 | E-GEOD-63455 | biostudies-arrayexpress
2020-08-12 | GSE152022 | GEO
2015-05-19 | GSE68991 | GEO