Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ATRX reduces the accessibility of HCMV genomes during lytic infections

ABSTRACT: We investigated the role of the chromatin remodeling protein ATRX on chromatin accessibility of HCMV genomes during the IE phase of lytic infections

ORGANISM(S): Homo sapiens

PROVIDER: GSE262839 | GEO | 2024/08/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

ATRX reduces the accessibility of HCMV genomes during lytic infections

Project description:ATRX reduces the accessibility of HCMV genomes during lytic infections

| PRJNA1093462 | ENA

Temporal Dynamics of HCMV Gene Expression in Lytic and Latent Infections

Project description:Primary infection with Human cytomegalovirus (HCMV) results in a persistent lifelong infection due to its ability to establish latent infection. During productive HCMV infection, viral genes are expressed in a coordinated cascade that is characteristic of all herpesviruses and traditionally relies on the dependencies of viral genes on protein synthesis and viral DNA replication. In contrast, the transcriptional landscape associated with HCMV latency is still disputed and poorly understood. Here, we examine viral transcriptomic dynamics during the establishment of both productive and latent HCMV infections. These temporal measurements reveal that viral gene expression dynamics along productive infection and their dependencies on protein synthesis and viral DNA replication, do not fully align. This illustrates that the regulation of herpesvirus genes does not represent a simple sequential transcriptional cascade and surprisingly many viral genes are regulated by multiple independent modules. Using our improved classification of viral gene expression kinetics in conjunction with transcriptome-wide measurements of the effects of a wide array of chromatin modifiers, we unbiasedly show that a defining characteristic of latent cells is the unique repression of immediate early (IE) genes. In particular, we demonstrate that IE1 (a central IE protein) expression is the principal barrier for achieving a full productive cycle. Altogether, our findings provide an unbiased and elaborate definition of HCMV gene expression in lytic and latent infection states.

2022-03-29 | GSE193467 | GEO

HCMV transcriptome during early lytic infection

Project description:Purpose: to investigate expression of HCMV and cellular RNAs at early times post-infection in a lytic model

2022-12-18 | GSE171520 | GEO

HCMV epigenome during early lytic infection

Project description:Purpose: to investigate occupancy of Pol II and H3K27Ac on the HCMV and cellular genomes at early times post-infection in a lytic model

2022-12-18 | GSE171512 | GEO

HCMV epigenome during early lytic infection

Project description:HCMV epigenome during early lytic infection

| PRJNA719827 | ENA

HCMV transcriptome during early lytic infection

Project description:HCMV transcriptome during early lytic infection

| PRJNA719840 | ENA

Temporal Dynamics of HCMV Gene Expression in Lytic and Latent Infections

Project description:Temporal Dynamics of HCMV Gene Expression in Lytic and Latent Infections

| PRJNA796314 | ENA

HCMV epigenome and transcriptome during early lytic infection

Project description:HCMV epigenome and transcriptome during early lytic infection

| PRJNA719833 | ENA

Role of the HCMV immediate early proteins in controlling the HCMV and cellular epigenomes

Project description:Purpose: to investigate the role of the HCMV immediate early proteins in controlling the HCMV and cellular epigneomes during lytic infectioin

2022-12-21 | GSE171518 | GEO

Cytomegalovirus promotes maintenance and growth of glioblastoma stem cells [HCMV gene expression]

Project description:Primary human GBM stem like cells were infected with HCMV TR strain (MOI=1) and treated with IE siRNA (a combination of oligos targeting IE1 and IE2 HCMV genes) 72 hours following siRNA treatment, RNA was harvested using Qiagen and divided equally for profiling using Affymetrix arrays and HCMV arrays.

2015-08-13 | GSE56750 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data