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Targeting RBM39 for Improved Outcomes as a Novel Therapeutic Strategy in T-cell acute lymphoblastic leukemia

ABSTRACT: Indisulam demonstrates significant antineoplastic properties in the context of T-cell acute lymphoblastic leukemia (T-ALL). Its effectiveness is primarily due to the degradation of RBM39, attenuating cell proliferation, promoting apoptosis and interfering with cell cycle progression in vitro, while facilitating tumor remission in T-ALL in vivo models.

ORGANISM(S): Homo sapiens

PROVIDER: GSE263309 | GEO | 2024/08/02

REPOSITORIES: GEO

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Exceptional response of high-risk neuroblastoma to RBM39 degrader Indisulam (RNA-Seq)

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