Transcriptomics

Dataset Information

0

Siglec-F+ neutrophils in the spleen induce immunosuppression following acute infection


ABSTRACT: The mechanisms underlying the increased mortality of secondary infections during the immunosuppressive phase of sepsis remain elusive. We established a mouse model of sepsis-induced immunosuppression followed by secondary infection. Compared to other organs, we observed a significant reduction in pro-inflammatory cytokines in the spleen, accompanied by a marked increase in IL-10 production, primarily by infiltrating neutrophils. Furthermore, we confirmed that these infiltrating neutrophils in the spleen during the immunosuppressive phase of sepsis undergo phenotypic change in the local microenvironment, exhibiting high expression of neutrophil biomarkers such as Siglec-F, Ly6G, and Siglec-E. These neutrophils subsequently produced IL-10 to suppress T lymphocytes. Depletion of neutrophils or specifically targeting Siglec-F leads to a notable improvement in the survival of mice with secondary infections. The identification of Siglec-F+ neutrophils as key regulators of immunosuppression following sepsis represents a novel finding with potential therapeutic implications.

ORGANISM(S): Mus musculus

PROVIDER: GSE264139 | GEO | 2024/04/24

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-03-16 | E-GEOD-79248 | biostudies-arrayexpress
2022-03-23 | GSE190700 | GEO
2024-03-01 | GSE227162 | GEO
2016-03-16 | GSE79248 | GEO
2016-01-15 | E-GEOD-64760 | biostudies-arrayexpress
2019-10-02 | E-MTAB-7483 | biostudies-arrayexpress
2018-12-26 | GSE115305 | GEO
2020-01-21 | GSE143943 | GEO
2023-05-22 | GSE229054 | GEO
2018-10-29 | GSE121311 | GEO