Transcriptomics

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A microbiota-derived bile acid controls hepatic cholesterol levels in cachectic mice


ABSTRACT: Our work showed decreased hepatic levels of TDCA in the C26 model of cancer cachexia. We also found gut microbiota composition alterations in cachectic C26 mice, as well as reductions in microbial 7α-dehydroxylase activity, and activity of 7α-HSDH and 12α-HSDH, which drive the production of secondary bile acids. Finally, we showed that TDCA administration induces lower hepatic levels of cholesterol in C26 mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE265876 | GEO | 2024/10/02

REPOSITORIES: GEO

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