Effect of Large Brown Adipocyte-secreted Proteins on Type 1 Diabetic Mice (NOD) inguinal white adipose tissue

ABSTRACT: Brown adipose tissue has been recognized as an important endocrine organ for metabolic health. In our study, we found that large proteins secreted by brown adipocyte (CB-100) promote the recovery of euglycemia in type 1 diabetic mice (NOD) when injected at an early stage of the disease. To further elucidate the in vivo effects of CB-100, we analyzed brown adipose tissue from both CB-100 and sham-treated mice. Differential gene expression analysis revealed that CB-100 treatment promote the adipocyte proliferation and browning wihtin inguinal white adipose tissue. This suggests that the recovery of euglycemia in CB-100-treated mice may be attributed to the recovery of healty white fat and its browning, which also contributes to glucose clearance

ORGANISM(S): Mus musculus

PROVIDER: GSE265914 | GEO | 2025/03/24

REPOSITORIES: GEO