Simultaneous treatment of castration-resistant prostate cancer cells with the DNA Demethylating Agent Decitabine and S-adenosylmethionine leads to synergistic anti- cancer effects.

ABSTRACT: A general problem of methylating and demethylating agents is a lack of limitation to the promotors of tumor suppressor genes or proto-oncogenes respectively. This may cause adverse consequences. Thus, the question was raised if the simultaneous application of DNA-demethylating agents and S-adenosylmethionine could reverse these effects.

ORGANISM(S): Homo sapiens

PROVIDER: GSE266129 | GEO | 2025/01/02

REPOSITORIES: GEO