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Gene expression profile at single cell level of primary regulatory T cells(CD25+CD127- Treg), primary induced regulatory T cells(iTreg), and AMRT treated iPSC-derived CD4+ T cells (iCD4+Treg-like)

ABSTRACT: We used single cell RNA sequencing (scRNA-seq) to analyze the difference among CD25+CD127-Treg, iTreg, and iCD4+Treg-like. We expanded CD25+CD127-Treg by TCR stimulation in the presense of AS2863619, anti-TNFR2 antibody, and TGFbeta (AMT). We differentiated iTreg from naive CD4+T cells and iCD4+Treg-like from iPSC-derived CD4+T cells in the presence of TCR stimulation, AS2863619, anti-TNFR2 antibody, TGFbeta, and rapamycin (AMRT).

ORGANISM(S): Homo sapiens

PROVIDER: GSE266541 | GEO | 2024/06/16

REPOSITORIES: GEO

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